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UV Ray Inhibition Shown with GliSODin® in New Human Study
MORRISTOWN, NJ (1 June, 2005) PL Thomas (PLT) today announced the results of a new study using its exclusive dietary supplement ingredient, GliSODin®, demonstrating significant reduction in susceptibility to sunburn in a model using UV radiation-induced skin changes.
In the double-blind, placebo controlled study, UV skin burn (actinic erythema) was induced on the inner-forearms of healthy subjects before supplementation with GliSODin or placebo, and each week for four weeks during supplementation. The color of the skin was measured by chromometry, and changes in skin due to inflammation were assessed by videocapillaroscopy, which calculates the congestion of small blood vessels.
According to the researchers, “This study confirms the efficacy of GliSODin in the prevention of the consequences of oxidative stress resulting from exposure to the sun. This efficacy is of particular interest for phototypes II (fair-skinned) that represent a major part of the consultations in dermatology.”
The researchers also noted the GliSODin was extremely fast-acting. The GliSODin and placebo supplementation were started just two to three days prior to the first UV irradiation, and despite such a short period there was a noticeable difference between the two groups.
GliSODin supplementation resulted in an increase in the minimum exposure to UV rays necessary to produce skin burn. In particular, phototypes II required eight times greater exposure than that of the placebo.
Further, the redness induced by the skin burn decreased more quickly in the GliSODin group and the increase in the number of capillaries assessed by videocapillaroscopy, demonstrating a reduction in inflammation, was higher in the GliSODin group compared to placebo.
The randomized double-blind study with 50 participants was conducted by researchers at Center Hospital University, Besançon, France, and was presented at the CARD (Annual Congress of Dermatological Research) meeting in Brest on May 28th. The study has been submitted for publication.
Previous published human and laboratory studies have shown GliSODin’s effectiveness in protecting cells from oxidative stress by activating the body’s production of its own antioxidants, including SOD, catalase and glutathione peroxidase.* This “internal antioxidant defense system” is necessary for the elimination of the free radicals produced by oxidative stress.
* References:
1) MUTH CM, GLENZ Y, KLAUS M, RADERMACHER P, SPEIT G, LEVERVE X. Influence of an Orally Effective SOD on hyperbaric Oxygen-related Cell Damage. Free Rad Res 2004; 38: 927-932.
2) VOULDOUKIS I, LACAN D, KAMATE C, COSTE P, MAZIER D, CONTI M, DUGAS B. Antioxydant and Anti-inflammatory properties of a cucumis melo extract rich in superoxyde dismutase activity. J Ethnopharmacol 2004; 94: 67-75
3) VOULDOUKIS I, CONTI M, KOLB JP, CALENDA A, MAZIER D, DUGAS B. Induction of Th-1dependent immunity by an orally-effective melon SOD extract. Res Trends – Curr Trends Immunol 2003; 5: 151-145.
4) VOULDOUKIS I, CONTI M, KRAUSS P, KAMATE C, BLAZQUEZ S, TEFIT M, MAZIER D, CALENDA A, DUGAS B. Supplementation with Gliadine-Combined Plant Superoxyde Dismutase Extract Promotes Anti-oxidant Defences and Protects against oxidative stress. Phytoterapy Res 2004; 18: 957-962.
Evaluation of the Effect of GliSODin® on the Intensity of
Actinic Erythema Induced with Radiation.
Besançon Study (46 KB)
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Evaluation of the Effect of GliSODin® on the Intensity of Actinic Erythema Induced with Radiation. (2,523 KB)
(PDF Download - Netscape Browsers, right click then select "Save Link Target As...")
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